The Center for Surgical Innovation was built as a joint endeavor by Dartmouth Hitchcock Medical Center, the National Institutes of Health, Dartmouth College’s Geisel School of Medicine, and Thayer School of Engineering. The Center for Surgical Innovation (CSI) offers a unique clinical environment that offers two fully integrated operating rooms with surgical navigation, a procedural suite, 3T Intraoperative MRI, and a 64 slice Intraoperative CT. The facility combines clinical and research environments allowing for the full spectrum of bench-to-bedside investigations aimed at improving the efficacy and safety of surgery. The CSI as a research facility has three distinctions: a controlled surgical environment with integrated multi-modal 3D imaging, operational engineering for safe co-location of research and clinical care, and the ability to progress though research to clinical applications in the same environment, with the same equipment.